HLA-targeted sequencing reveals the pathogenic role of HLA-B*15:02/HLA-B*13:01 in albendazole-induced liver failure: a case report and a review of the literature
oleh: Jin-Mao Liao, Yan Zhan, Yan Zhan, Yan Zhan, Yan Zhan, Zheng Zhang, Jia-Jia Cui, Jia-Jia Cui, Jia-Jia Cui, Jia-Jia Cui, Jia-Jia Cui, Ji-Ye Yin, Ji-Ye Yin, Ji-Ye Yin, Ji-Ye Yin
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2023-11-01 |
Deskripsi
Drug-induced liver injury (DILI) is one of the serious adverse drug reactions (ADRs), which belongs to immune-mediated adverse drug reactions (IM-ADRs). As an essential health drug, albendazole has rarely been reported to cause serious liver damage. A young man in his 30 s developed severe jaundice, abnormal transaminases, and poor blood coagulation mechanism after taking albendazole, and eventually developed into severe liver failure. The patient was found heterozygous of HLA-B*15:02 and HLA-B*13:01 through HLA-targeted sequencing, which may have a pathogenic role in the disease. This case report summarizes his presentation, treatment, and prognosis. A useful summary of the diagnosis and associated genetic variant information is provided.