ZEB1 protects skeletal muscle from damage and is required for its regeneration
oleh: Laura Siles, Chiara Ninfali, Marlies Cortés, Douglas S. Darling, Antonio Postigo
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-03-01 |
Deskripsi
Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role for Zeb1 in maintenance of satellite cell quiescence.