Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes
oleh: Dan Zhao, Kerui Wu, Sambad Sharma, Fei Xing, Shih-Ying Wu, Abhishek Tyagi, Ravindra Deshpande, Ravi Singh, Martin Wabitsch, Yin-Yuan Mo, Kounosuke Watabe
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-12-01 |
Deskripsi
The molecular mechanisms explaining racial disparity in breast cancer mortality are not completely elucidated. Here, the authors show that an African-associated SNP in American breast cancer patients, leads to higher levels of microRNA miR-1304-3p which promotes cancer by increasing lipids availability.