Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts
oleh: Kentaro Kitano, Dana M. Schwartz, Haiyang Zhou, Sarah E. Gilpin, Gregory R. Wojtkiewicz, Xi Ren, Cesar A. Sommer, Amalia V. Capilla, Douglas J. Mathisen, Allan M. Goldstein, Gustavo Mostoslavsky, Harald C. Ott
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-10-01 |
Deskripsi
There is a need for humanised grafts to treat patients with intestinal failure. Here, the authors generate intestinal grafts by recellularizing native intestinal matrix with human induced pluripotent stem cell-derived epithelium and human endothelium, and show nutrient absorption after transplantation in rats.