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Florfenicol (Nuflor®) a fluoroanalogue of thiamphenicol was evaluated in the treatment of bovine respiratory tract infections at 20 mg per kg body weight deep intramuscular of 48 h interval in nine animals. There was recovery in eighf animals out of nine. Out of 29 bacterial isolates of nasal washings of these animals, nine were Gram positive and 12 were Gram negative organisms. Treatment resulted in a rapid fall in group mean rectal temperature and improved clinical condition of the cases. After therapy the haematological parameters of recovered animals showed significant difference with respect to erythrocyte sedimentation rate and packed cell volume