Deep dissection of the antiviral immune profile of patients with COVID-19
oleh: Djordje Atanackovic, Stephanie V. Avila, Forat Lutfi, Diego de Miguel-Perez, Xiaoxuan Fan, Gabriela Sanchez-Petitto, Erica Vander Mause, Jonathan Siglin, John Baddley, Heather D. Mannuel, Hanan Alkhaldi, Kim G. Hankey, Rena Lapidus, Michael Kleinberg, Joseph Rabin, Carl Shanholtz, Christian Rolfo, Aaron P. Rapoport, Saurabh Dahiya, Tim Luetkens
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-12-01 |
Deskripsi
Atanackovic and coauthors screen COVID-19 patients for antibodies against 9 different SARS-CoV-2 proteins observing responses against the spike (S) proteins, the receptor-binding domain (RBD), and the nucleocapsid (N) protein which were of the IgG1 and IgG3 subtypes. They also characterised immune responses in these patients and their findings will help to identify the most relevant component of the anti-SARS-CoV-2 humoral immune response as well as assist the design of immunomonitoring methods for anti-COVID-19 vaccines.