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A cross-sectional study was conducted to determine the prevalence of Carbapenem-resistant Gram-negative bacteria (CR-GNB) in animals. The study involves one hundred eighty-four GNB isolates from 214 samples (feces, milk, pus, and uterine discharge) from Buffalo (N=112), Cattle (N=50), and Dog (N=52). Healthy and diseased animals reported to Veterinary Clinical Complex were sampled. Carbapenemase production was evaluated by phenotypic methods and the presence of Metallo β-lactamase genes was assayed by PCR. We observed a 9.78% overall prevalence of CR-GNB in animal sources. CR-GNB was more frequently recovered from companion animals (19.23%) when compared to livestock (4.93%). IMP (44.4%), VIM (38.8%), and OXA-48 (16.66 %) were the main MBLs observed in the study.