Generation of a human induced pluripotent stem cell line (VRFi001-A) from orbital adipose tissue of a bilateral retinoblastoma patient with heterozygous RB1 gene deletion
oleh: Ambily Vincent, Vikas Khetan, Pukhraj Rishi, Ganesan Suganeswari, Subramanian Krishnakumar, Uma Maheswari Krishnan, Sowmya Parameswaran
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2018-05-01 |
Deskripsi
Retinoblastoma (RB) is a pediatric intraocular tumor caused by mutations in retinoblastoma (RB1) gene. We have generated induced pluripotent stem cell line VRFi001-A from a bilateral retinoblastoma patient with heterozygous RB1 gene deletion. The iPSC line VRFi001-A retained the mutation and expressed pluripotency markers, had a normal karyotype and was capable of trilineage differentiation.