Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
oleh: Farah H. Siddiqi, Fiona M. Menzies, Ana Lopez, Eleanna Stamatakou, Cansu Karabiyik, Rodrigo Ureshino, Thomas Ricketts, Maria Jimenez-Sanchez, Miguel Angel Esteban, Liangxue Lai, Micky D. Tortorella, Zhiwei Luo, Hao Liu, Emmanouil Metzakopian, Hugo J. R. Fernandes, Andrew Bassett, Eric Karran, Bruce L. Miller, Angeleen Fleming, David C. Rubinsztein
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-04-01 |
Deskripsi
A key challenge is to find/re-purpose approved drugs that could be used in humans to induce autophagy-associated clearance of neurodegenerative proteins. Here, authors demonstrate that felodipine, an anti-hypertensive drug, can induce autophagy and clear a variety of aggregated neurodegenerative disease-associated proteins in mouse brains at plasma concentrations similar to those that would be seen in humans taking the drug.