Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus

oleh: José P. Guirao-Abad, Martin Weichert, Ginés Luengo-Gil, Sarah Sze Wah Wong, Vishukumar Aimanianda, Christina Grisham, Nikita Malev, Shivani Reddy, Laura Woollett, David S. Askew

Format: Article
Diterbitkan: American Society for Microbiology 2021-10-01

Deskripsi

The fungal UPR is an adaptive signaling pathway in the ER that buffers fluctuations in ER stress but also serves as a virulence regulatory hub in species of pathogenic fungi that rely on secretory pathway homeostasis for pathogenicity. This study demonstrates that the gene encoding the ER-localized P5-type ATPase SpfA is a downstream target of the UPR in the pathogenic mold A. fumigatusA. fumigatus