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In this paper, we propose an iterative relay scheduling with hybrid ARQ (IRS-HARQ) scheme, which realizes fast jump-in/successive relaying and subframe-based decoding under the multiple user equipment (UE) relay environments applicable to the next-generation cellular systems (e.g., LTE-advanced and beyond). The proposed IRS-HARQ aims to increase the achievable data rate by iteratively scheduling a relatively better UE relay closer to the end user in a probabilistic sense, provided that the relay-to-end user link should be operated in an open-loop and transparent mode. The latter is due to the fact that not only there are no dedicated control channels between the UE relay and the end user, but also a new cell is not created. Under this open-loop and transparent mode, our proposed protocol is implemented by partially exploiting the channel state information based on the overhearing mechanism of acknowledge/negative acknowledge for HARQ. Further, the iterative scheduling enables UE-to-UE direct communication with proximity that offers spatial frequency reuse and energy saving.