Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones

oleh: Alexander A. Fadeev, Alexey O. Chagarovskiy, Anton S. Makarov, Irina I. Levina, Olga A. Ivanova, Maxim G. Uchuskin, Igor V. Trushkov

Format: Article
Diterbitkan: MDPI AG 2020-12-01

Deskripsi

A simple general method for the synthesis of 1-acyl-2-(<i>ortho</i>-hydroxyaryl)cyclopropanes, which belong to the donor–acceptor cyclopropane family, has been developed. This method, based on the Corey–Chaykovsky cyclopropanation of 2-hydroxychalcones, allows for the preparation of a large diversity of hydroxy-substituted cyclopropanes, which can serve as promising building blocks for the synthesis of various bioactive compounds.