Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension
oleh: Aline C. Oliveira, Tao Yang, Jing Li, Ravindra K. Sharma, Marianthi K. Karas, Andrew J. Bryant, Annette D. deKloet, Eric G. Krause, Bina Joe, Elaine M. Richards, Mohan K. Raizada
| Format: | Article |
|---|---|
| Diterbitkan: | Wiley 2022-01-01 |
Deskripsi
Abstract Recent evidence suggests pulmonary hypertension (PH), a disease of the pulmonary vasculature actually has multiorgan pathophysiology and perhaps etiology. Herein, we demonstrated that fecal matter transplantation from angiotensin‐converting enzyme 2 overexpressing mice counteracted the effects of chronic hypoxia to prevent pulmonary hypertension, neuroinflammation, and gut dysbiosis in wild type recipients.