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Background Antimicrobial resistance is a growing concern globally, leading to more difficult-to-treat infections and higher mortality rates. Urinary tract infections (UTI) are one of the major indications for prescribing antibiotics, with multidrug resistant Gram-negative bacilli being responsible for a growing proportion of community-acquired uncomplicated UTIs. Our goal is to determine nitrofurantoin, a less costly effective substitute in treating uncomplicated UTI caused by multidrug resistant gram negative bacilli.