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<h4>Objectives</h4>Reliable biomarkers for renal fibrosis are needed for clinical care and for research. Existing non-invasive biomarkers are imprecise, which has limited their utility.<h4>Methods</h4>We developed a method to quantify fibrosis by subject size-adjusted CT Hounsfield units. This was accomplished using CT measurements of renal cortex in previously irradiated non-human primates.<h4>Results</h4>Renal cortex mean CT Hounsfield units that were adjusted for body size had a very good direct correlation with renal parenchymal fibrosis, with an area under the curve of 0.93.<h4>Conclusions</h4>This metric is a promising and simple non-invasive biomarker for renal fibrosis.