Catalytic enantioselective reductive domino alkyl arylation of acrylates via nickel/photoredox catalysis

oleh: Pengcheng Qian, Haixing Guan, Yan-En Wang, Qianqian Lu, Fan Zhang, Dan Xiong, Patrick J. Walsh, Jianyou Mao

Format: Article
Diterbitkan: Nature Portfolio 2021-11-01

Deskripsi

Enantioenriched α-aryl propionic acids are an important class of nonsteroidal anti-inflammatory medications. Here the authors use a visible-light-promoted photoredox/nickel catalyzed method to form such compunds via a three-component alkyl arylation of acrylates.