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In order to study the sensitivity of factors affecting the homogeneous building slope stability, the orthogonal test design method and shear strength reduction finite element method were used. The stability safety factor of the slope was used as the analysis index, and the range analysis of results of 18 cases were carried out. The results show that the order of sensitivity of slope stability factors is: internal friction angle, slope height, cohesion, slope angle, bulk density, elastic modulus, Poisson's ratio. The analysis results have reference significance for the design and construction of building slope projects.