SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice
oleh: Mariana Baz, Nikita Deshpande, Charlie Mackenzie-Kludas, Francesca Mordant, Danielle Anderson, Kanta Subbarao
| Format: | Article |
|---|---|
| Diterbitkan: | Centers for Disease Control and Prevention 2022-11-01 |
Deskripsi
We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection.