Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour

oleh: Ikuko Takeda, Kohei Yoshihara, Dennis L. Cheung, Tomoko Kobayashi, Masakazu Agetsuma, Makoto Tsuda, Kei Eto, Schuichi Koizumi, Hiroaki Wake, Andrew J. Moorhouse, Junichi Nabekura

Format: Article
Diterbitkan: Nature Portfolio 2022-07-01

Deskripsi

Astrocytes may contribute to synaptic remodelling in the cortex in chronic pain states. Here the authors describe modulation of astrocyte activity to drive circuit reorganization in somatosensory cortex in mice, along with peripheral nerve block, which could be a potential therapeutic approach for the treatment of chronic pain.