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China’s National Agricultural Science and Technology Parks (NASTPs) play a key role in improving the nation’s agro-industrial structure and regional economic development; notably, NASTPs can demonstrate innovations in modern agricultural science and technology and, relatedly, incubate emerging modern agri-industries. However, after more than 20 years of development, scholars have not yet to confirm whether NASTPs contribute to local economies. This study sought to explore the impact of NASTPs on county economic development, to identify the mechanisms behind this impact, and to verify these effects using a multi-period double difference method based on panel data from 1743 counties in China collected between 2000 and 2019. The study found that the NASTPs significantly improved county economic development. The policy effects were mainly evident in western regions and counties with higher levels of financial resources. No spatial spillover effects were observed. The NASTPs drove county economic growth through three main channels: agglomeration, institutional environment, and innovation effects. These findings provide insights useful for designing policies related to the high-quality construction of agricultural sci-tech parks, the high-quality growth of county economies, and a reduction in regional economic development gaps.