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Two previously undescribed caryophyllane-related sesquiterpenoids, antipacids A (<b>1</b>) and B (<b>2</b>), with a novel bicyclo[5.2.0] core skeleton, and known compound clovane-2β,9α-diol (<b>3</b>), along with rumphellolide L (<b>4</b>), an esterified product of <b>1</b> and <b>3</b>, were isolated from the organic extract of octocoral <i>Rumphella antipathes</i>. Their structures, including the absolute configurations were elucidated by spectroscopic and chemical experiments. In vivo anti-inflammatory activity analysis indicated that antipacid B (<b>2</b>) inhibited the generation of superoxide anions and the release of elastase by human neutrophils, with IC₅₀ values of 11.22 and 23.53 μM, respectively, while rumphellolide L (<b>4</b>) suppressed the release of elastase with an IC₅₀ value of 7.63 μM.