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&nbsp; The psychoneuromedulator role of corticotrophin releasing hormone in women with Polycystic Ovary Farideh Zafari Zangeneh1*, Mohammad Mehdi Naghizadeh2 Masoumeh Masoumi1 Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Community Medicine, Medical Faculty, Fasa University of Medical Sciences, Fasa, Iran Address: Reproductive Health Research Center, Imam Hospital Complex, Keshavarz Blvd., Tehran, Iran. &nbsp;&nbsp;&nbsp; E-mail: Zangeneh14@gmail.com Tel. +982166581616 Fax No.: +982166581658 Abstract Background: Polycystic ovary syndrome (PCOS) is a common complex condition in women associated with reproductive and metabolic systems and also psychological disorders. There is considerable evidence to suggest that the sympathetic nervous system is involved in PCO and metabolic syndroms. Noradrenalin (NA), corticotrophin releasing hormone (CRH) and nerve growth factor (NGF) are the strong stimulants for two axes: hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-ovarian (HPO) axes which are regulators for the female reproductive system. Following previous studies on sympathetic nervous system overactivity in PCOS, the main purpose of this study is to evaluate the role of CRH and NGF as two important findings from the perspective of the psycho-emotional. Methods: This case/control study has been down in Reproductive Health Research Center of Imam Khomeini Hospital, Tehran, Iran in 2015. 170 women participated in this study with 20-40 years of age and body mass index (BMI) of less than 28. Data analysis was using by t-tests, Chi-square and Mann Whitney. &nbsp; Results: Serum levels CRH and NGF in patients with polycystic ovary was significantly lower than the control group (p<0.001). This reduction can disrupt two neural axes and the sympathetic nervous system activity and&nbsp; have a&nbsp; fundamental role in psycho-emotional reactions in women with PCOS. Moreover, using demographic questionnaire quantitative and qualitative characteristics of the population studied, the results of which are reported in the regression model. &nbsp; Conclusions: The results of this study confirmed previous studies. This reduction in serum levels of CRH and NGF shows the hyperactivity of sympathetic nervous system in polycystic ovary syndrome can be one of the causes of mental disorders in women with PCOS. &nbsp;