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Higher levels of D-dimers and beta-thromboglobulin may predict thromboembolic events in patients with non-valvular atrial fibrillation(6). D-dimers are markers of thrombogenesis. RE-LY and ARISTOTLE substudies described the correlation between the levels of D-dimers and the risk of stroke, cardiovascular death and major hemorrhagic events outcomes(5). In ARISTOTLE substudy, D-dimers levels were related to stroke, major bleeding, and mortality, independent of the oral anticoagulant treatment(7). A multi marker strategy may improve and refine the risk stratification in patients with atrial fibrillation. The ABC-stroke risk score has been validated in some studies as a better tool for predicting stroke and systemic embolism in patients with atrial fibrillation(8). This score includes two blood biomarkers, NT-proBNP and cardiac troponin-hs, and two clinical variables, age and prior stroke.