HIF-2α is indispensable for regulatory T cell function
oleh: Tzu-Sheng Hsu, Yen-Lin Lin, Yu-An Wang, Shu-Ting Mo, Po-Yu Chi, Alan Chuan-Ying Lai, Hsuan-Yin Pan, Ya-Jen Chang, Ming-Zong Lai
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
HIF-1α is known to repress regulatory T (Treg) cell function, but less is known about the effect of HIF-2α on these cells. Here, the authors use three different mouse models of inflammatory diseases to show that HIF-2α limits HIF-1α expression and is critical for Treg cell function.