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Solar wind turbulence is often perceived as weakly compressible and the density fluctuations remain poorly understood both theoretically and observationally. Compressible magnetohydrodynamic simulations provide useful insights into the nature of density fluctuations. We discuss a few important effects related to 3D simulations of turbulence and in situ observations. The observed quantities such as the power spectrum and variance depend on the angle between the sampling trajectory and the mean magnetic field due to anisotropy of the turbulence. The anisotropy effect is stronger at smaller scales and lower plasma beta. Additionally, in situ measurements tend to exhibit a broad range of variations, even though they could be drawn from the same population with the defined averages, so a careful averaging may be needed to reveal the scaling relations between density variations and other turbulence quantities such as turbulent Mach number from observations.