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In order to describe and understand possible problems associated with deafblindness we applied a functional analysis case formulation strategy and Functional Analytic Clinical Case Diagrams (FACCD). We collected clinical assessment data from deafblind persons who were experiencing multiple psychological problems as reported by their healthcare professionals. The data were collected after the healthcare professionals were trained in functional analyses and in applying FACCD. The 21 deafblind persons assessed by healthcare professionals were reported to have 3–11 psychological problems. Two case examples are given to illustrate the complexity of a deafblind person's life situation and the functional relations among problems and possible causal variables. Thus, in addition to vision, hearing and communication problems, deafblindness can be associated with other psychological problems that may benefit from more precise psychological assessment and treatment. We found that the functional analysis and FACCD were useful in helping assess and understand persons with visual and hearing difficulties, especially when there are indications of concomitant psychological problems.