Reprogramming of pancreatic adenocarcinoma immunosurveillance by a microbial probiotic siderophore
oleh: Mehdi Chaib, Bilal B. Hafeez, Hassan Mandil, Deidre Daria, Ajeeth K. Pingili, Sonam Kumari, Mohammed Sikander, Vivek K. Kashyap, Guo-Yun Chen, Emmanuel Anning, Manish K. Tripathi, Sheema Khan, Stephen Behrman, Murali M. Yallapu, Meena Jaggi, Liza Makowski, Subhash C. Chauhan
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
The probiotic-derived siderophore, ferrichrome, enhances anti-tumor immunity and improves the efficacy of checkpoint immunotherapy in a model of pancreatic cancer by repolarizing tumor-associated macrophages to a immunostimulatory M1 phenotype.