Hypocholesterolemia and Inflammatory Biomarkers Act as Predictors of Severe Vitamin D Deficiency in Patients With Crohn’s Disease: A Clinical Analysis of 862 Patients in China

oleh: Jie Lu, Jie Lu, Fei Yu, Fei Yu, Jun Huang, Jun Huang, Haitao Yu, Haitao Yu, Fengying Li, Fengying Li, Zhi’an Le, Zhi’an Le, Yulan Cheng, Yulan Cheng, Qi Zhang, Qi Zhang, Guiling Li, Guiling Li, Xinyou Xie, Xinyou Xie, Huifang Tang, Huifang Tang, Huifang Tang, Jun Zhang, Jun Zhang

Format: Article
Diterbitkan: Frontiers Media S.A. 2022-04-01

Deskripsi

BackgroundIn this study, we enrolled 862 patients with Crohn’s disease (CD) in China to investigate the correlation between serum vitamin D (SVD) and serum lipids, inflammatory biomarkers, and important clinical parameters.Materials and Methods25(OH)D was measured by LS/MS/MS. Correlation analysis, chi-square tests, and logistic regression analysis were performed to determine the correlations between vitamin D and potential risk factors when vitamin D levels were lower than 10 ng/mL or 20 ng/mL.ResultsThe incidence of severe vitamin D deficiency (SVD < 10 ng/mL) in patients with CD was significantly higher than that in healthy controls (28.9 vs. 9.5%). Multinomial logistic regression analysis showed that penetrating disease [odds ratio (OR) = 2.18], low levels of high-density lipoprotein cholesterol (HDL) (OR = 1.91), high erythrocyte sedimentation rate (OR = 1.73), and platelet count (PLT) (OR = 2.71) were regarded as predictors of severe vitamin D deficiency, while only PLT (OR = 1.90) and HDL (OR = 1.76) were considered as predictors of mild vitamin D deficiency (SVD 10–20 ng/mL).ConclusionOur results confirm a higher incidence of severe vitamin D deficiency in patients with CD in China and show that vitamin D deficiency could result from the combined effects of penetrating disease, inflammation, and low levels of HDL.