Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals
oleh: Jennifer Connors, David Joyner, Nathan J. Mege, Gina M. Cusimano, Matthew R. Bell, Jennifer Marcy, Bhavani Taramangalam, Kenneth M. Kim, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Michele A. Kutzler, Mohamad-Gabriel Alameh, Elias K. Haddad
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-02-01 |
Deskripsi
The role of empty lipid nanoparticles in eliciting dendritic cell maturation and innate immune signaling is shown to be impaired in older adults, potentially contributing to lower immune responses to SARS-CoV-2 mRNA-based vaccines.