Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy
oleh: Swayam Prakash Srivastava, Han Zhou, Ocean Setia, Bing Liu, Keizo Kanasaki, Daisuke Koya, Alan Dardik, Carlos Fernandez-Hernando, Julie Goodwin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-04-01 |
Deskripsi
The endothelial glucocorticoid receptor plays a key role in the regulation of many diseases, including diabetes. Loss of this receptor results in accelerated renal fibrosis, a heightened inflammatory milieu, augmented Wnt signaling and suppression of fatty acid oxidation in diabetic kidneys.