Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90+ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis
oleh: Yuanlong Li, Qingqiang Tu, Dongmei Xie, Shurui Chen, Kai Gao, Xiaochun Xu, Ziji Zhang, Xifan Mei
| Format: | Article |
|---|---|
| Diterbitkan: | BMC 2022-03-01 |
Deskripsi
Highlights Long-term injection of glucocorticoids in the knee joint cavity promotes loss of cartilage content. CD90-positive stem cell vesicles encapsulated with Triamcinolone acetonide-loaded nanoparticles have good materials. T-CD90@NPs drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis. T-CD90@NPs regulate the polarization of type 2 macrophages to resist inflammation. T-CD90@NPs promote chondrocyte regeneration through the FOXO signaling pathway.