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The aim of this study was to develop a Brain Computer Interface (BCI) application to control domotic devices usually present at home. Previous studies have shown that people with severe disabilities, both physical and cognitive ones, do not achieve high accuracy results using motor imagery-based BCIs. To overcome this limitation, we propose the implementation of a BCI application using P300 evoked potentials, because neither extensive training nor extremely high concentration level are required for this kind of BCIs. The implemented BCI application allows to control several devices as TV, DVD player, mini Hi-Fi system, multimedia hard drive, telephone, heater, fan and lights. Our aim is that potential users, i.e. people with severe disabilities, are able to achieve high accuracy. Therefore, this domotic BCI application is useful to increase