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Low vaccine acceptance remains a public health threat, which is still common among healthcare workers. Therefore, the purpose of this review is to determine the level of COVID-19 vaccine acceptance among healthcare professionals in Ethiopia. This review was reported using the PRISMA checklist. Eleven articles were retrieved, then extracted on Excel, and exported to STATA version 11 software for meta-analysis. The pooled prevalence of vaccine acceptance and it is 95% CI were presented using forest plots. Tests to check heterogeneity and publication bias were done. The estimated pooled prevalence of COVID-19 vaccine acceptance among healthcare professionals in Ethiopia with a random-effects model was 54.59% (95% CI: 42.49, 66.69) through a heterogeneity index (I2) of 99.1% (p < .001), which is relatively low. Therefore, it is important to identify and remove any myths or obstacles preventing healthcare professionals from accepting the COVID-19 vaccination.