5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus
oleh: R. Blake Billmyre, Shelly Applen Clancey, Lucy X. Li, Tamara L. Doering, Joseph Heitman
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
The authors show that resistance to the antifungal 5-fluorocytosine in Cryptococcus deuterogattii is acquired more frequently in isolates with elevated mutation rate, and is associated with alterations in capsule biosynthesis and nucleotide metabolism.