Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
oleh: Rocío Rojo, Anna Raper, Derya D. Ozdemir, Lucas Lefevre, Kathleen Grabert, Evi Wollscheid-Lengeling, Barry Bradford, Melanie Caruso, Iveta Gazova, Alejandra Sánchez, Zofia M. Lisowski, Joana Alves, Irene Molina-Gonzalez, Hayk Davtyan, Rebecca J. Lodge, James D. Glover, Robert Wallace, David A. D. Munro, Eyal David, Ido Amit, Véronique E. Miron, Josef Priller, Stephen J. Jenkins, Giles E. Hardingham, Mathew Blurton-Jones, Neil A. Mabbott, Kim M. Summers, Peter Hohenstein, David A. Hume, Clare Pridans
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
The lineage-specific receptor CSF1R controls macrophage development and homeostasis. Here the authors show that deletion of a conserved Csf1r enhancer (FIRE) selectively depletes brain microglia and resident macrophages in the epidermis, kidney, heart and peritoneum of otherwise healthy mice.