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INTRODUCTION Therapies for the management of heart failure have been responsible for the great benefit experienced by the population in terms of hope and quality of life. However, they are nothing more than palliative measures that have not resolved the tissue destruction due to this problem whose malignity causes 20 million cardiac deaths worldwide every year.1 Reparative and regenerative medicine was born over 2 decades ago as a biological response to the pressing need for innovation in this field. Its objective is to orchestrate diagnostic tools and therapeutic strategies to restore the molecular, cellular, and tissue health of the cardiac organs damaged.2