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AbstracPurpose: The purpose of this study was to acsess the rate of acceptance of Information Systems Research (pazhoohan) by Mashhad University of Medical Sciences faculty members based on the technology acceptance model (TAM).Methodology: This study used a survey method. Sample volume was 248 of Mashhad University of Medical Sciences faculty members appointed through stratified random sampling method. Data were through a questionnaire. The overall Cronbach's alpha coefficient was calculated as be 95%. To analyze the data, descriptive and inferential statistics were used SPSS and LISRER.Results: No significant relation was observed among MUMS and acceptance of pazhoohan system according to individual factors. The level of acceptance by nonclinical MUMS was more than clinical members. The share rate of TAM internal structures differences was observed and the highest differences was related to the perceived ease of use of the system. the perceived ease of use and perceived usefulness of the pazhoohan system was significant correlation. Finaly the results confirmed the applicability of TAM factors in use of Pazhoohan system.Keywords: Technology acceptance, Pazhoohan system, Mashhad University of Medical Sciences, Technology Acceptance Model (TAM).