Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer
oleh: Gianluca Civenni, Giuseppina M. Carbone, Carlo V. Catapano
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2019-09-01 |
Deskripsi
The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial fission and sustaining CSC expansion. These findings provide a new paradigm for developing novel treatment strategies for prostate cancer.