Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression
oleh: William W. Greenwald, He Li, Paola Benaglio, David Jakubosky, Hiroko Matsui, Anthony Schmitt, Siddarth Selvaraj, Matteo D’Antonio, Agnieszka D’Antonio-Chronowska, Erin N. Smith, Kelly A. Frazer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-03-01 |
Deskripsi
It is currently unclear how quantitative changes in chromatin loop propensity contribute to differential gene regulation. Here, the authors use phased Hi-C, RNA-seq, and ChIP-seq to show that subtle changes in loop propensity associate with differential gene regulation across cell types and haplotypes.