Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters
oleh: Yu-Ping Lin, Daniel Bakowski, Gary R. Mirams, Anant B. Parekh
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-06-01 |
Deskripsi
Endoplasmic reticulum Ca2+ sensing STIM proteins and plasma membrane Orai1 channels together regulate Ca2+ influx in eukaryotic cells. Here authors show that two Ca2+-dependent transcription factors, NFAT1 and c-fos, have different requirements for the number of STIM1-Orai1 clusters and on the Ca2+ flux through the clusters.