An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR
oleh: Zhaoqi Kang, Manman Zhang, Kaiyu Gao, Wen Zhang, Wensi Meng, Yidong Liu, Dan Xiao, Shiting Guo, Cuiqing Ma, Chao Gao, Ping Xu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
L-2-hydroxyglutarate (L-2-HG) is an important metabolite but its regulation is poorly understood. Here the authors report an L-2-HG FRET biosensor based on the allosteric transcription factor, LhgR, to monitor L-2-HG in cells and biological samples.