BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
oleh: Fred C. Lam, Yi Wen Kong, Qiuying Huang, Tu-Lan Vu Han, Amanda D. Maffa, Ekkehard M. Kasper, Michael B. Yaffe
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-08-01 |
Deskripsi
In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage checkpoint signaling in oncogenic cells.