The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
oleh: Kader Salifou, Swagat Ray, Laure Verrier, Marion Aguirrebengoa, Didier Trouche, Konstantin I. Panov, Marie Vandromme
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-01-01 |
Deskripsi
Histone methylation regulates gene expression. Here, Salifou et al.show that KDM4A, a histone lysine demethylase, regulates RNA polymerase I-driven transcription in a PI3K dependent manner, therefore linking nutrients and growth factors availability to ribosomal RNA transcription.