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Background and Aim: As the acceptance and commitment therapy (ACT) helps improve psychological well-being, the effectiveness of this approach has drawn the attention of many researchers recently. This study aimed at evaluating the effectiveness of ACT on psychological well-being and anger reduction among mothers with deaf children in Tehran. Methods: Thirty mothers of deaf children, who met the inclusion criteria, were randomly divided into control and experimental groups (15 women per group). For the experimental group, ten sessions of ACT on anger reduction were held, whereas the control group received no education in this respect. Their psychological well-being level and anger reduction level were evaluated before and after the intervention using Ryff scales of psychological well-being and the multidimensional anger inventory (MAI), respectively. Results: The ACT affected the psychological well-being and anger reduction among mothers with deaf children and persisted at follow-up (p<0.001). Conclusion: This study indicates the importance of using these interventions in the case of mothers with deaf children and providing new horizons in the interventions. In other words, ACT has a performance compatible with many variables.