1,2,3-Triazoles as leaving groups: SNAr reactions of 2,6-bistriazolylpurines with O- and C-nucleophiles
oleh: Dace Cīrule, Irina Novosjolova, Ērika Bizdēna, Māris Turks
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2021-02-01 |
Deskripsi
A new approach was designed for the synthesis of C6-substituted 2-triazolylpurine derivatives. A series of substituted products was obtained in SNAr reactions between 2,6-bistriazolylpurine derivatives and O- and C-nucleophiles under mild conditions. The products were isolated in yields up to 87%. The developed C–O and C–C bond forming reactions clearly show the ability of the 1,2,3-triazolyl ring at the C6 position of purine to act as leaving group.