A cell fitness selection model for neuronal survival during development
oleh: Yiqiao Wang, Haohao Wu, Paula Fontanet, Simone Codeluppi, Natalia Akkuratova, Charles Petitpré, Yongtao Xue-Franzén, Karen Niederreither, Anil Sharma, Fabio Da Silva, Glenda Comai, Gulistan Agirman, Domenico Palumberi, Sten Linnarsson, Igor Adameyko, Aziz Moqrich, Andreas Schedl, Gioele La Manno, Saida Hadjab, François Lallemend
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-09-01 |
Deskripsi
Programmed cell death is an important part of tissue development, and traditionally it is considered that neuronal death is a stochastic process in response to neurotrophic factor deprivation. Here the authors show that for TrkC+ proprioreceptors, which neurons die is predetermined molecularly by how much TrkC is present, as well as by a gene expression signature.