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In recent years, the active compounds from the plants and fruits, which have been used in the human foods regimen, have received increased attention in medical research. Therefore, the side effects of chemical drugs and their complications have persuaded the scientists to look into the active compounds of fruits and plants, to find their useful effects in prevention and treatment of different diseases. One of such compounds is resveratrol, a natural poly phenol found prefavorably in grapes and berries. Its useful effects on metabolic syndrome, including cardiovascular diseases, fatness and T2DM, have been extensively studied in animal models and human clinical trials. In fact the results from numerous studies have shown that resveratrol may be useful in the prevention and even treatment of type 2 Diabetes. Over the past two decades, the results of investigations conducted on animal models and clinical trials on human and, meta analysis applied, regarding the effectiveness of resveratrol in reducing fasting blood sugar and insulin resistance have been promising. Therefore, in this review I will discuss the useful effects of resveratrol and its mechanism of action on type 2 Diabetes and related parameters, in different models including animals and human clinical trials.