Perfluorinated Brønsted 'Superacids': Powerful Catalysts for the Preparation of Vitamin E
oleh: Thomas Netscher, Werner Bonrath, Alois Haas, Eike Hoppmann, Horst Pauling
| Format: | Article |
|---|---|
| Diterbitkan: | Swiss Chemical Society 2004-03-01 |
Deskripsi
The key-step in the industrial synthesis of (all-rac)-?-tocopherol (synthetic vitamin E) is the condensation reaction of trimethylhydroquinone with the C20 building block isophytol. For this Friedel-Crafts-type reaction, perfluorinated NH- and CH-acidic compounds (perfluoroalkyl(aryl)sulfonyl imides and methides) have been applied as excellent catalysts, preferably in biphasic solvent systems.