The route to transcription initiation determines the mode of transcriptional bursting in E. coli

oleh: Christoph Engl, Goran Jovanovic, Rowan D. Brackston, Ioly Kotta-Loizou, Martin Buck

Format: Article
Diterbitkan: Nature Portfolio 2020-05-01

Deskripsi

Transcription noise in bacteria is often attributed to burstiness, but the mechanisms are unclear. Here, the authors show that the transition from low to high expression can be regulated via burst size or burst frequency, depending on the mode of transcription initiation determined by different sigma factors.