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Epididymal-fat-pad adipose tissue obtained from obese-hyperglycemic mice exhibited an impairment in its ability to mobilize free fatty acids (FFA) when incubated with epinephrine and in response to a 16-hour fast. Unexpectedly, FFA production by adipose tissue of fed obese mice was significantly greater than that observed in adipose tissue obtained from lean littermates. It is suggested that the impaired mobilization of FFA may be implicated in the etiology of this type of obesity.